BACKGROUND
Treatments for alopecia are in high demand, but not all are safe and reliable.
Dalteparin and protamine microparticles (D/P MPs) can effectively carry growth
factors (GFs) in platelet-rich plasma (PRP).
OBJECTIVE
To identify the effects of PRP-containing D/P MPs (PRP&D/P MPs) on hair growth.
METHODS&MATERIALS
Participants were 26 volunteers with thin hair who received five local
treatments of 3 mL of PRP&D/P MPs (13 participants) or PRP and saline (control,
13 participants) at 2- to 3-week intervals and were evaluated for 12 weeks.
Injected areas comprised frontal or parietal sites with lanugo-like hair.
Experimental and control areas were photographed. Consenting participants
underwent biopsies for histologic examination.
RESULTS
D/P MPs bind to various GFs contained in PRP. Significant differences were seen
in hair cross-section but not in hair numbers in PRP and PRP&D/P MP injections.
The addition of D/P MPs to PRP resulted in significant stimulation in hair
cross-section. Microscopic findings showed thickened epithelium, proliferation
of collagen fibers and fibroblasts, and increased vessels around follicles.
CONCLUSION
PRP&D/P MPs and PRP facilitated hair growth but D/P MPs provided additional hair
growth. The authors have indicated no significant interest with commercial
supporters.
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