Ketoconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.
Ketoconazole is used to treat a number of different types of fungal and yeast infections. Ketoconazole shampoo is used to treat skin conditions that are caused by infection with the yeast Pityrosporum. These include the skin infection pityriasis versicolor, as well as seborrhoeic dermatitis and dandruff, which is considered to be a mild form of seborrhoeic dermatitis.
Ketoconazole shampoo should be used to wash the affected areas and left for three to five minutes before rinsing. For dandruff and seborrhoeic dermatitis, the shampoo should be used to wash the hair twice weekly for two to four weeks. Once these conditions have cleared up they can be prevented from coming back by using the shampoo once every one to two weeks.
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