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February 4, 2004
Comparative studies on level of androgens in
hair and plasma with premature male-pattern baldness.
Bang HJ, Yang YJ, Lho DS, Lee WY, Sim WY, Chung BC.
Bioanalysis and Biotransformation Research Center, Korea Institute of Science
and Technology, P.O. Box 131, Cheongryang, 130-650, Seoul, South Korea
BACKGROUND: It is well known that male-pattern baldness (MPB) is not started
from occipital, but frontal or scalp of head. We can assume that distribution of
androgenic steroids is different for each region of the head.
OBJECTIVE: We
hypothesize that the levels of androgenic steroids are different not only
between vertex hair with MPB and controls but also between occipital hair with
MPB and controls. Moreover, we want to search for the biochemical indicator in
plasma and hair sample (baldness: 22, non-baldness: 13) obtained from
dermatology of medical center. After then, we desire to present fundamental data
regarding diagnosis, medical cure, and prevention for premature MPB.
METHODS:
After hair and plasma were hydrolyzed, and then extracted with organic solvent.
To assess androgenic steroids levels, we used gas chromatography-mass
spectrometry (GC-MS) system in selected ion monitoring mode.
RESULTS: The level
of dihydrotestosterone (DHT) and the ratio of testosterone to epitestosterone
(T/E ratio) in vertex hair from premature baldness subjects were higher than in
the sample of non-baldness subjects (P<0.001, 0.001), whereas the levels of
androgens in occipital hair from the same baldness group were not different. In
addition, we discovered the levels of DHT, testosterone, and DHT/T ratio in
plasma from premature MPB were higher than in those of control subjects
(P<0.001, 0.001, 0.005).
CONCLUSION: We verified that the distribution of
androgenic steroids is unlike in various regions of individual subjects.
Moreover, the increased DHT/T ratio in balding plasma indirectly confirms the
high activity of 5alpha-reductase type II.
PMID: 14757277 [PubMed - in process]
 
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